Best Doctors in India for Neurofibromatosis Treatment
Best Hospitals in India for Neurofibromatosis Treatment
- City: Bengaluru, India
Hospital Highlights:
- Fortis Hospital Bannerghatta, Bengaluru was established in 2006.
- The hospital is a 276 bedded multi-specialty tertiary care facility.
- The hospital specializes in cutting-edge medical technology and dedicated patient care services.
- The hospital is equipped with state-of-the-art technologies like trans-radial angioplasty, trans-abdominal cardiac surgery, and computerized TKR navigation surgery.
- The hospital provides specialty medical services in cardiology, cardiac surgery, orthopedics, neurology, neuro-surgery, GI, and Minimal Access Surgery (MAS).
- City: Chennai, India
Hospital Highlights:
- Fortis Malar was established in 1992 and was formerly known as Malar Hospital.
- The hospital specializes in cutting-edge medical technology and dedicated patient care services.
- The hospital is multi-specialty, tertiary care facility with 180 beds.
- The hospital offers comprehensive medical care in specialties such as cardiology, cardio-thoracic surgery, neurology, neurosurgery, orthopedics, nephrology, gynecology, gastroenterology, urology, pediatrics, and diabetes.
- City: New Delhi, India
Hospital Highlights:
- Established in 1996, Pushpawati Singhania Research Institute is one of the top hospitals in the NCR region, as well as one of the top facilities in India for gastroenterology. The hospital is one of South Asia’s first institutes in medical and surgical treatment for diseases related to digestion.
- The hospital is equipped with state-of-the art facilities coupled with the latest equipment as well as renowned consultants from various parts of India as well as other parts of the world.
- City: New Delhi, India
Hospital Highlights:
- State-of-the-art technology and devoted healthcare professionals have been brought together under one roof at Venkateshwar Hospital to provide genuine medical care. The hospital’s professionals work together as a team to deliver the best possible treatment to their patients, using the most sophisticated equipment and information technology.
- Venkateshwar Hospital’s mission is to attain global excellence in healthcare by employing evidence-based, ethical clinical practices and cutting-edge technology by a team of highly skilled experts.
- City: New Delhi, India
Hospital Highlights:
- Sir Ganga Ram Hospital, New Delhi is known to provide the latest medical procedures with the latest technology in all of its units.
- The hospital has a team of reputed doctors, nurses, and healthcare professionals that ensure that patients receive quality care at affordable costs.
- Staffed with a team of highly qualified doctors, dedicated nurses, and paramedical and non-medical staff, the hospital aims to lead in healthcare delivery, medical education, training, and research.
- As per the vision of the founder, the hospital also provides free treatment to the economically weaker sections of society.
- Sir Ganga Ram Hospital also provides training to young doctors under the Diplomate in National Board(DNB) program. The DNB program at the hospital was started in 1984 and it is known for currently running the maximum number of DNB specialties in the country. It also has the distinction of having the first bone bank in India.
- City: Kerala, India
Hospital Highlights:
- Established in 2019, Apollo Adlux Hospital is the first Apollo Hospital in Kerala and the 73rd hospital owned by Apollo Group in India. With the state’s most advanced, comprehensive healthcare infrastructure and cutting-edge technologies, Apollo Adlux Hospital stands as an example of medical excellence in Kerala.
- With over 34 multi-specialty departments, the hospital believes in providing the best quality treatment to its patients at affordable rates, ensuring comfort at their difficult times.
- The 300-bed hospital is managed by a team of highly qualified and experienced experts who delivers exceptional hospitality to their patients and treats them with great compassion.
- With its affiliation with the Apollo Hospitals Group, the hospital aims in providing patients with top-notch healthcare services while also serving communities in Kerala.
- The hospital has good railway and road connections, and is conveniently close to Cochin International Airport.
- City: Gurugram, India
Hospital Highlights:
- Situated near DLF Cyber City, Gurugram, Narayana Superspecialty Hospital is one of the top medical facilities in the Delhi NCR region, catering to the needs of the people. Known for its commitment to quality medical care and patient service, the hospital is a state-of-the-art facility with planned and well-equipped sections, which includes a spacious OPD area as well as comfortable patient rooms.
- It is the closest super-specialty hospital from Indira Gandhi International Airport towards Gurugram, and also the nearest super specialty hospital from DLF Cyber City. It is also close to major residential areas in Gurugram.
- It is part of the renowned Narayana Health Group. Established in 2000, by Dr. Devi Shetty, a renowned cardiac surgeon, it has grown to be one fo India’s leading healthcare groups.
- City: Noida, India
Hospital Highlights:
- Fortis Hospital, Noida, stands as one of the oldest and most trusted healthcare institutions in the region, setting a benchmark for comprehensive medical care.
- As the second mega hub hospital in the Fortis Healthcare Group, Fortis Hospital, Noida, upholds a legacy of trust among more than 1.2 million patients. By integrating top-tier professionals with cutting-edge technology, the hospital delivers superior treatment across various medical disciplines.
- Specializing in advanced Neurosciences, Orthopedics, Kidney and Liver Transplant Programmes, Fortis Hospital, Noida has successfully performed over 1,500 transplants, solidifying its reputation as a leader in specialized medical interventions.
Neurofibromatosis
Neurofibromatosis is an incurable genetic disorder that affects the entire nervous system. It can affect the development of nerve cell tissues. It also leads to tumors known as neurofibromas to develop on the nerves, which can lead to various other problems.
In some cases, they might be harmless but they might also cause serious damage if they compress the nerves as well as other tissues.
The disorder is of three types, i.e. Nf1, Nf2 and schwannomatosis, though they are not related.
Symptoms
The symptoms of neurofibromatosis can vary, depending on the type.
The disorder can spread throughout the whole body, causing tumors as well as unusual skin pigmentation. It can manifest as bumps as well, under the skin, colored sports, bone problems, pressure on spinal nerve roots, as well as other neurological problems.
In some cases, patients can also face learning disabilities, behavioral problems, or vision or hearing loss.
NF1 – When this type of neurofibromatosis affects an individual, he/she may show a skin condition but no other related medical problems. Birthmarks and freckles are common as well, among people with this condition. Freckles might appear at an unusual location, such as the groin, under the breasts, or in the armpits. People with this type of neurofibromatosis are also at a higher risk of hypertension or high blood pressure.
NF2 – NF2 is a more serious condition in which tumors grow on nerves deep inside the body. There might be several symptoms such as facial numbness, weakness, paralysis, hearing loss, loss of balance and vertigo, tinnitus, etc.
As the tumor grows, the symptoms might get worse. Tumors may also sometimes develop on the brain, skin, and spinal cord, with potentially serious consequences. Cataracts might also occur, as well as learning disabilities and behavioral problems. Tumor sometimes develops rapidly, but some grow slowly, and the effect might not be noticeable for several years.
Schwannomatosis – It is a rare form of neurofibromatosis, that generally affects less than 1 in 40,000 people. It is generally different from NF1 and NF2. This can cause pain, tingling, numbness, or weakness in the finger and toes.
Causes
The cause of neurofibromatosis is genetic defects or mutations that are either passed on by a parent or occur spontaneously during conception.
NF1- The NF1 gene is located on chromosome 17 and this gene produces a protein termed neurofibromin that helps regulate cell growth. The mutated gene causes a loss of neurofibromin, which allows cells to grow uncontrolled.
NF2- The NF2 gene is located on chromosome 22, and it produces a protein which is termed merlin, also called a schwannomin, which helps in suppressing tumors. The mutated gene can lead to a loss of merlin, lead which can cause uncontrolled cell growth.
Schwannomatosis- Two genes are generally known to cause schwannomatosis. Mutations of the genes SMARCB1 and LZTR1, which helps to suppress tumors, are associated with this type of neurofibromatosis.
Diagnosis
For NF1
Generally, NF1 is normally diagnosed during one’s childhood. A diagnosis is generally confirmed when an individual has at least two of the following:
- A family history of NF1
- Lesions in the bone
- A glioma, or tumor, on the optic nerve, which is mostly without symptoms
- At least six “café-au-lait” spots which measure over 5 millimeters across in children or 15 millimeters in adolescents or adults
- Freckling in the armpits, in the groin area, or under the breast
- At least two Lisch nodules, or small brown spots in the iris
- Two or more neurofibromas, or one “plexiform”
Plexiforms affect around 25 percent of people who have Nf1. Plexiforms are neurofibromas that spread around the large nerves as they grow, which leads to the nerve becoming thick and misshapen. They generally feel like knots or cords under the skin. They can be large as well as painful, and also disfiguring. Plexiform generally start forming during childhood.
A special type of lamp is used to check for any skin marks. Other diagnostic tools that your doctor can use include an X-ray, CT, or MRI scan. A genetic blood test might be required as well.
For NF2
Symptoms of NF2 generally appear around puberty or during adulthood. The most common age of onset is generally between 18 to 24 years.
Diagnosis of NF2 can be made when there is:
- An acoustic neuroma in one of the ears, along with two or more typical symptoms, such as cataracts, brain tumors, and a family history of the condition
- Acoustic neuroma along with brain or spinal tumors, which can be detected by an MRI or CT scan
- An acoustic neuroma in both the ears
- A faulty gene, which is identifiable through a blood test
A person having NF2 will be referred to a neurologist. Hearing and eye tests might also be conducted to check for cataracts, other eye problems, and hearing problems.
Treatment
Since there is no permanent cure for neurofibromatosis, treatments generally focus on the symptoms. Some of the symptoms generally do not need any treatment. Some of the options for treatment can include the following:
- Surgery for removing problem growths or tumors
- Treatment which can include chemotherapy or radiation if a tumor has turned malignant, or cancerous
- Surgery for bone problems, such as scoliosis
- Therapy which can include physical therapy or counseling
- Surgery for cataracts
- Auditory brainstem and cochlear implants
- Aggressive treatment of pain linked to the condition
- Stereotactic radiosurgery